GENOME-WIDE ANALYSIS UNCOVERS RECURRENT ALTERATIONS IN PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMAS (PCNSL)
نویسندگان
چکیده
منابع مشابه
Genome-Wide Analysis Uncovers Novel Recurrent Alterations in Primary Central Nervous System Lymphomas.
PURPOSE Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin lymphoma confined to the central nervous system. Whether there is a PCNSL-specific genomic signature and, if so, how it differs from systemic diffuse large B-cell lymphoma (DLBCL) is uncertain. EXPERIMENTAL DESIGN We performed a comprehensive genomic study of tumor samples from 19 immunocompetent PCNSL patien...
متن کاملFrequent Alterations of the p14 and p16 Genes in Primary Central Nervous System Lymphomas
To elucidate the role of p53/p16/RB1 pathways in the tumorigenesis of primary central nervous system lymphomas (PCNSLs), we have analyzed p14, p16, RB1, p21, and p27 status in a series of their 18 sporadic cases of diffuse large B-cell lymphoma, using methylationspecific PCR, differential PCR, and immunohistochemistry. Homozygous deletion or methylation of p14 was detected in 10 (56%) PCNSLs, a...
متن کاملHuman Cancer Biology Recurrent Mutations of MYD88 and TBL1XR1 in Primary Central Nervous System Lymphomas
Purpose: Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance. Experimental Design: We investigated a series of 29 newly diagnosed, HIV-negative, PCNSL patients usinghigh-resolution single-nucleotide polymorphism (SNP) arrays (n1⁄429) andwhole-exome sequencing (n1⁄4 4) approaches. Recurren...
متن کاملRecurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas.
PURPOSE Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance. EXPERIMENTAL DESIGN We investigated a series of 29 newly diagnosed, HIV-negative, PCNSL patients using high-resolution single-nucleotide polymorphism (SNP) arrays (n = 29) and whole-exome sequencing (n = 4) approaches. Recurre...
متن کاملEfficacy of Procarbazine, Lomustine, and Vincristine Chemotherapy for Recurrent Primary Central Nervous System Lymphomas
BACKGROUND Optimal treatment for recurrent primary central nervous system lymphomas (PCNSLs) has not been defined yet and there is no general consensus about the salvage chemotherapy after high-dose methotrexate (HD-MTX)-based chemotherapy. The purpose of the present study was to evaluate the efficacy and safety of procarbazine, lomustine, and vincristine (PCV) chemotherapy for recurrent PCNSLs...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2014
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/nou209.7